The authors studied on the seismic activity，precursory anomalies and abnormal animal behavior before the Yushu MS7. 1 earthquake on April 14，2010． Analysis showed that anomalies were not rich before the Yushu MS7. 1 earthquake，but those observed were prominent． There were MS6. 0，MS5. 0 and MS4. 0 seismic calm regions of long and medium-term trend anomalies． Precursor anomalies included Yushu and Delingha surface temperatures and Ping'an electromagnetics． There were a large number of animals macro phenomenon week before the earthquake． There was a MS4. 7 earthquake 130 minutes before the main shock． The authors studied the dynamic process of Yushu earthquake preparation with the Bayan Har block boundary earthquake focal mechanism since 1996． The results showed that the Karakorum MS7. 1 earthquake 1996，the Mani MS7. 5 earthquake and the Yushu MS7. 1 earthquake were events in the same dynamic process． And long and medium-term trend anomalies may be related to the dynamics of the evolution of different earthquakes． The paper also discusses strong earthquake recurrence interval， foreshock identification and precursor observation of Yushu MS7. 1 earthquake．