In this paper, we introduce the geological structure, focal mechanisms of historical earthquakes and geodynamic setting of Tienshan and its neighboring region, and draw a conclusion of the large earthquakes in the Tienshan seismic zone governed mainly by the pushing from Hindu Kush-Pamir syntax. We then investigate the relationship of large earthquakes in the Hindu Kush-Pamir and Tienshan seismic zone, and find the synchronization features is existing in grouped large earthquakes between the two regions. The relationship of intermediate-focus large earthquakes in Hindu Kush-Pamir and shallow large earthquakes in Tienshan seismic zone is also discussed. The same synchronization characteristics is also found between the two, and the intensity and frequency of intermediate-focus earthquakes is fiercer. Large earthquakes in the Tienshan seismic zone are more intense, and the distribution range is also wider. The above results confirm the geodynamic correlativity between the Hindu Kush-Pamir and the Tienshan seismic zone from the viewpoint of seismieity.