The water level rising rate of Tangshan mine well significantly accelerated in 2010, and the ascensional range was obviously higher than the same period in previous years. From the point of view of groundwater dynamics and loading effects, using the pumping （pouring） water test model and semi-infinite elastic space theory model under uniform load, grouting and loading of the near building construction were analyzed. Results represent that range of 200 - 700m grouting, daily grouting 2500m3 , grouting 270d, can cause rising change in 8 - 11 m of well water level, and loading of large area of the near building can cause about 4m changes of well water level. The analysis of these factors shows that water level anomalous rising of Tangshan mine well was relevant to grouting and loading of the near building construction. This study provides a scientific basis for anomalous rising analysis of water level in Tangshan mine wells.