In this paper，the probability gain is synthesized by the forecasting method of heterogeneity parameter Kcv of spatial distribution of earthquake and Pattern Informatics algorithm， which provides a way of predicting the ML≥5. 0 earthquake probability gain from 2013 to 2017 in Hebei Province and its adjacent areas． According to earthquake observation data of more than 40 years in Hebei Province and its adjacent areas，the efficiency of earthquake prediction for the seismic spatial heterogeneity index method is researched by spatial scanning Kcv-value and earthquake cases statistics，and then the ML≥5. 0 earthquake probability gain forecasting from 2013 to 2017 in Hebei Province and its adjacent areas is provided． The retrospective test of Pattern Informatics algorithm for seismic hazard probability prediction in the study area is carried out，the prediction R-value and probability gain K value of the method is obtained，and the forward prediction for five years is given． Finally，synthetical prediction results of the ML≥5. 0 earthquake probability gain are obtained for the next 5 years in Hebei Province and its adjacent areas by the prediction of comprehensive probability gain of the above two single prediction methods．