According to the statistical results of historical earthquakes(294～1969，M≥4?) and modern earthquakes(1970～2013，MS≥3.5)in Anhui Province，the paper，by estimating the types of historical earthquake sequence，divides the earthquakes in Anhui into the comparatively safe class and the comparatively dangerous class. The results showed that the historical earthquake classes and the characteristics of spatial distribution in the Anhui region accord with those of modern earthquake sequence. The majority of historical strong earthquakes belong to “comparatively safe class”，and historical earthquakes of “comparatively safe class” are mainly located in the Huoshan area，northeast area of Anhui and northern area of Suzhou city. It can be concluded that the seismic activity in the Anhui region has higher inheritance，and the results from this study can provide a reference for the regional quick post seismic tendency judgment.