Using the satellite thermal infrared brightness temperature data before and after the Lop M_S6.0 earthquake,and taking into consideration of the weather factors,we analyze the time-varying spatial distribution and intensity of anomalies. The results show that the anomalies,which distributed like stripes with the same northwest-southeast orientation of fault zones,mainly located to the northwest of the epicenter and the areas of high value located in the vicinity of Bachu. Anomalies appeared 14 days before the earthquake and showed relatively strong initially. After a weak period,the anomalies reached the highest value and then decreased quickly and disappeared. So it can be concluded as two anomalies. The first one lasted for a short time and the second one lasted for 4 days,with prominent differences compared with normal values. According to the results,the anomalies correlate with the Lop earthquake very well in all respects of temporal and spatial evolution.