Based on the co-seismic water level response followed by the Jiuzhaigou M_S7.0 earthquake and the Jinghe M_S6.6 in Xin Well 10, we obtained the hydrogeological parameters of Xin Well 10-aquifer system by tidal analysis and seismic wave analysis. The mechanism of co-seismic response of Xin Well 10 caused by the two earthquakes was discussed. Our main conclusions include:the water level of Xin Well 10 showed different co-seismic response to the Jiuzhaigou earthquake and the Jinghe earthquake. The hydraulic conductivity of Xin Well 10 aquifer obtained by horizontal flow model was 61m/d in the Jiuzhaigou earthquake and 147m/d in the Jinghe earthquake, indicating that the seismic wave led to the enhanced permeability in horizontal direction. The vertical hydraulic conductivity of aquifer in Xin Well 10 by using the vertical flow model was approximately 49×10^-5m/d before the two earthquakes, and was about 18×10^-5 m/d after the earthquake, showing that the earthquake caused vertical permeability decease. Therefore, the co-seismic response of water level in Xin Well 10 is related to the change of aquifer permeability caused by seismic wave.