The load/unload response ratio(LURR)theory is a promising method for predicting earthquakes by characterizing the extent of damage in the focal area. Based on the load/unload response ratio theory, the spatial-temporal evolution characteristics of LURR abnormality before the Jinghe M_S6.6 earthquake occurred on August 9, 2016 were analyzed, and the seismogenic integral of the abnormal area was analyzed. The results show that there are a few LURR abnormal areas in the studied area before the Jinghe M_S6.6 earthquake, and the anomaly area is annular or flaky. With the abnormal development, abnormal areas migrate near the source. During the process of abnormal evolution, 6 earthquakes with M ≥ 5.0 occurred within and around the anomalous area, of which 2 earthquakes with M ≥ 6.0 occurred in the process of abnormal high value weakening, and the characteristic time T₂ from abnormal peak value to the main shock are 11 months and 22 months, which are greater than the theoretical occurrence time of the earthquake. This shows that the tectonic activity in the study area is intense, and the seismicity of the area is very active.