The error of soil shear wave velocity is inevitable,and it can be up to 30%. At present,the design of shear wave velocity error or the design of soil layer model is somewhat idealized on the study of the influence of shear wave velocity error on soil layer seismic response calculation results. In order to present the real soil condition more precisely,we built the soil layer model based on the measured shear wave velocity,and used the Monte Carlo method to investigate the influence of the shear wave velocity errors on seismic response spectra. In this paper,soil layer models of 132 sites distributed uniformly in Shandong Province were built,including site type Ⅱ and site type Ⅲ. Based on the Monte Carlo method,100 groups of shear wave velocity values are randomly generated in the deviation range of 30% of the measured shear wave velocity for each site. Then,the seismic response calculation of soil layers models including these shear wave velocity values were carried out,and the changes of response spectra and response spectra platform values and characteristic periods were analyzed. The result shows that,the maximum influence from the random errors less than 30% of soil shear wave velocity on response spectra in some periods is generally more than 30%,and the maximal influence on response spectra platform values is generally 10%~50%,the maximal influence on characteristic periods of site type Ⅱ is generally 0%~50%,and the maximal influence on characteristic periods of site type Ⅲ is generally 20%~90%.