Mud volcanoes are formed in specific hydrogeological and tectonic settings. Its eruption activity is a release of abnormal high pressure caused by a large amount of internal gas accumulation,and it can carry a lot of underground information to the surface,so it is known as "Heaven granted well". The real-time observation of the surroundings of the Xinjiang Wusu Aiqigou mud volcano began in August 2011. There have been 4 earthquakes with M_S6.0~7.0 within 200m since the observation:they are the November 1,2011 Nilka M_S6.0 earthquake,the June 30,2012 Xinyuan M_S6.6 earthquake,the December 8,2016 Hutubi M_S6.2 earthquake and the August 9,2017 Jinghe M_S6.6 earthquake. Before and after the 4 earthquakes,the macroscopic anomalies of "background value-rise-turn-down-background value" have appeared in the eruption activities of the Aiqigou mud volcano. The earthquakes during the process appeared from the strong to the weak of the mud volcanic eruption,and especially during the 2017 Jinghe M_S6.6 earthquake,the abnormal change of the eruption activity of the Wusu Aiqigou mud volcano is one of the basis for the determination of the earthquake situation in Xinjiang. It has played a certain role in predicting effectiveness of disaster reduction.