This paper introduces a comprehensive approach to short-term earthquake prediction. The basic idea is to use short-term anomalies with low false alarm rate as "fuze". After one or more "fuze" anomalies occur, the location and magnitude of the earthquake are comprehensively determined according to other anomalies. The advantage of this method is the high success rate of the comprehensive forecast. In this paper, taking the real-time pre-earthquake tracking process of the Gaoyou-Baoying, Jiangsu earthquake with M_S4.9 in 2012 and the Sheyang, Jiangsu earthquake with M_S4.4 in 2016 as an example, the application of this idea is introduced in detail in this paper. This method is of practical significance for tracking short-term earthquake conditions in the future.