Firstly,we utilized the historical earthquake events(M_W>4.0(1962-2016))derived from the Harvard University GCMT database,the published papers and the Crust2.0 model to obtain and research their different crustal depth seismicity distributions between Himalaya and the Tienshan by the statistic analysis method. Meanwhile,we used the static satellite gravity models GGM03S/EGM2008 and the TOPO model provided by GFZ Research Center to respectively calculate several different gravity anomaly fields and simulate the free-air gravity anomaly fields and the Bourger gravity anomaly fields basing on the different crustal elastic parameters. The results showed that horizontal and vertical gradient features of the crustal anomaly fields of the Himalayan region is far greater than that of the Tienshan region,and the average effective elastic plate thickness T_e(6-15km),in the Himalayan region,is less than the average effective elastic plate thickness T_e(20-30km),in the Tienshan region. Finally,we used the interseismic GPS 3-D velocity field to constrain and simulate the fault geometry and the kinematic model,and the results showed the great difference of the fault locking depth and the strain accumulation has existed in the different tectonic areas of the Qinghai-Tibetan Plateau,particularly,in the Himalayan Orogenic Belt and the Tienshan Orogenic Belt. Therefore,the crustal seismogenic dynamics of the margin area of the Qinghai-Tibetan Plateau and its adjacent region should have a dramatic correlation with the crustal effective elastic plate thickness;the seismogenic faults geometric and dynamic parameters and the block stress and strain accumulation.