Based on the regional earthquake ground motion attenuation relation,the site effect and the earthquake intensity and many factors,we eestablished a prediction model of earthquake damage,and developed a set of earthquake damage prediction system. Taking the earthquake damage prediction of the Jinghe M_S6.6 earthquake,Xinjiang on August 9,2017 as an example,the prediction results are compared with the current mainstream system. The results show that the ShakeMap_CNST system can make more accurate estimation in terms of the influence scope and intensity. Compared with other systems,the system results are very close to the field survey results in casualties,affected population estimates,number of emergency placement and evaluation of economic losses.