Based on the S-transform,the typical data affected by rainfall,gale,barometric pressure and seismic wave in fixed deformation observation are used to analyze and discuss the the time-frequency response characteristics of the four main interference of deformation in central Inner Mongolia. The results show that:the rainfall interference is distributed in low frequency band,and its frequency increases first and then decreases. The gale interference is distributed in high frequency band,and its the energy intensity in time-frequency domain is proportional to the variation range of the observation curve affected by the gale interference. The dominant frequency of barometric interference signal is distributed in the frequency;the VP vertical pendulum and the JCZ seismometer record similar seismic waves,but the frequency band of VP vertical pendulum record is less than that of JCZ seismometer,and the VP vertical pendulum mainly records low frequency seismic wave. Also,the variation of frequency and energy intensity with time of the four interference factors is consistent with that of the observation curve with time in time domain.