In this paper, the seismic activity and observations in geophysics anomalies detected before the Minxian-Zhangxian M_S6.6 earthquake of July 22, 2013 in Gansu Province were summarized. In terms of seismic activity, there were significant anomalies. For example, the large-scale M_S5 seismic quiescence is broken, M_S5 and M_L4 seismic gaps are broken, and M_L3 seismic quiescence is remarkably disturbed. In terms of observation in geophysical anomalies, the number of new anomalies in precursors has gradually increased since 2010 and reached the maximum in mid-2011. The ratio of anomaly items is the highest in the range of distance in 50～150km from the epicenter. The spatial-temporal evolution of observations in geophysical anomalies has obvious three-stage characteristics, that is, the α-stage anomaly has the characteristics of outward expansion, the β-stage manifests itself as a large-scale anomaly in a short period; the γ-phase manifests itself as an anomalous to epicenter contraction in the far-source region (γ₁), and the characteristics of the anomalous outward expansion of the near-source region (γ₂). The understanding of the evolutional characteristics of these anomalies can directly guide the earthquake tracking and prediction work, such as the seismic activities occurring before the earthquake (such as the seismic gap nesting of different magnitudes) and observations in geophysical anomaly distribution area have certain predictive indications for the earthquake location. Anomalous images of small and moderate-scale earthquakes (such as the M3 seismic quiescence and M4 seismic gap) and significant short-term anomalies (such as the quasi-synchronized transitional anomalies of the observations in geophysical anomalies, the temporal and spatial migration of precursors, short-term population anomalies, etc.) have certain guiding significance for the urgency of earthquake occurence.