Since the basic data usually could not be possible to update in time, it is difficult for traditional earthquake disaster loss assessment system to provide accurate assessment results. With increasingly improving technological means, it is the time for us to be able to achieve real-time earthquake disaster loss assessment by using satellite-drone-ground multi-source disaster information obtained from earthquake sites. Through the design of system construction, service function and service procedure, a prototype system has been developed to provide real-time earthquake disaster assessment based on multi-source disaster data. This system is helpful for government to obtain real-time disaster information (including degree of building damage, casualties, economic loss and so on), as well as to carry out earthquake and disaster relief work.