In this paper, we analyze the spatial and temporal distribution characteristics of earthquake hazards in Chinese mainland over the past 30 years based on data on earthquake disaster losses(including economic losses, human casualties and injuries) from 1990 to 2020. After analyzing the temporal distribution of economic losses from earthquake disasters in Chinese mainland between 1990-2019 by using conventional standardized methods, and combing with the original data on economic losses, human casualties(including missing persons), and human injuries during this time interval, we believed that earthquake disasters are gradually changing from threats to physical safety to economic property over the past 30 years. Through compiling and analyzing the spatial distribution characteristics of earthquake hazards by province during the 10-year period 2011-2020, we concluded that it is necessary to further strengthen the earthquake precaution in Sichuan, Yunnan, and Gansu to enhance their ability to withstand the seismic risk of disasters. In the more economically developed regions in the central-east, we should raise theattention on the indirect economic losses and human injuries caused by earthquakes, since the social impacts of earthquake hazards are the main consequences. By extracting the topographic slope factors by province and using geostatistical methods to quantify the spatial correlation coefficients between earthquake losses and topographic slope factors, we found that correlation of deaths due to earthquakes with topography is not as high as that of indirect losses. the spatial correlation between direct losses and topography is not as high as that of indirect losses because of the rapid economic development recently.