Using multi-period GSP observation data from "Crustal Movement Observation Network of China" and from GPS stations installed by the earthquake agency of Xnjiang Uygur Autonomous Region in the Keping block area located in the southwest Tianshan mountain, we calculated and obtained the distribution characteristics of locking fraction and slip deficit rate of the three major faults of Keping, Piqiang and Maidan around the Keping block by applying inversion calculation software—Defnode based on the principle of negative dislocation inversion. The calculated result by the inversion software is consistent with the actual observed data with the residual error about 1mm in the places with dense GPS sites. The results shows that keping fault has a stable change in fault locking, with a complete locking depth within 20km, a partial fault locking between 20km and 40km, and a fully creeping state below 40km. The Piqiang Fault has a fault locking depth of less than 10km, a partial locking state between 10km and 30km, and a fully creeping state below 30km, in which the slip deficit rate is between 0 and 2mm/a. The fault locking situation of the Maidan fault is complicated, in which the fault locking depth gradually decreases from the southwest segment to the northeast end, and gradually decreases from 35km to less than 10km.