A M_S6.8 earthquake hit Luding county,Sichuan Province of southwest China,at 12:52 pm September 5^th of Beijing Time,causing heavy casualties and attracting widespread public opinion. The Party and the government attach great importance to emergency information release and public opinion guidance. The information disclosure efficiency of public emergencies affects and even determines the development of public opinion on event handling. In order to bring enlightenment and thinking to the news publicity of earthquake prevention and disaster reduction in the future,in this paper,taking China Earthquake Networks Center as the main body of public opinion guidance. We analyze the public opinion of the Luding M_S6.8 earthquake,summarize the experience of public opinion guidance,and explore the role of public opinion guidance in earthquake departments to effectively carry out earthquake emergency response.