Fluid inclusions in minerals record many kinds of information about formation and evolution of paleofluids in the Earth,environment of mineral formation,etc. Measurement of fluid inclusions by the techniques of micro area and trace amount analysis can help to obtain information about earthquake and fault activities. Investigation of paleoearthquake using analyzing fluid inclusion in minerals in veins can extend the time scale for studying earthquake recurrence period,which is significant for seismic study. So far,seismic researches of fluids mainly concern correlation between law of fluid variations (water and gas) in the macro regions and earthquakes,but rarely for trace fluids in minerals. In this paper we briefly introduced fluid role in earthquake and fault activities and techniques for analyzing fluids inclusions,and reviewed advance of investigations for earthquake and fault using analyzing techniques of fluids inclusions,and finally suggested the further related research aspects.