By extracting the abnormal information from satellite hyperspectral data before the Tangshan M5.1 earthquake on July 12,2020,we found that overall CH₄, CO, H₂O, and O₃ had high-value anomalies before the earthquake. The anomalies are all found near the epicenter,and the anomaly amplitudes are 2 times higher than the mean square error. The abnormal mechanism of CH₄,CO and H₂O is different from that of O₃. Based on statistics of the frequency of occurrence of the three gases CH₄,CO,and H₂O from 2018 to 2020,we believe that the synchronization anomaly is reliable. The synchronization of hyperspectral multi-parameter abnormality can improve the reliability of abnormality determination. Through continuous tracking of different parameters,it has certain reference significance for short-term earthquake prediction.