The previous earthquake disaster assessment system mostly carries out the earthquake disaster assessment in the way of setting earthquakes,which cannot meet the business needs of the earthquake disaster assessment of the entire administrative region with different intensities in the earthquake disaster risk assessment. In this paper,taking the previous calculation model as the skeleton,based on the GIS platform with ArcEngine,we apply C/S structure to design the seismic disaster assessment system under different intensity based on residential area. The system takes the residential area as the evaluation unit. For each selected assessment area,the system evaluates the damage of buildings and casualties of earthquake disasters in the five grades of Ⅵ,Ⅶ,Ⅷ,Ⅸ and ≥Ⅹ. The results can provide technical support for governments at all levels and relevant departments to carry out regional earthquake risk assessment and earthquake disaster pre assessment.