In this article,we establish the prediction indexes system of moderately strong earthquakes in northwest Yunnan by using analytic hierarchy process(AHP),based on the earthquake cases in China and the research results of existing predictor indexes,and obtain the weight of each prediction index and the earthquake comprehensive judgment index Y,and tested the prediction efficiency of the comprehensive judgment index. The results show that:①With the fully consideration of the commonness and group characteristics of anomalies in the analytic hierarchy process structure we obtained the relative importance ranking of 16 prediction indicators. The prediction index with relatively large weight values are hydrochemical jump anomaly,precursory anomaly quasi-synchronization,small earthquake activity anomaly in the short-term prediction index,as well as fixed-point deformation anomaly and fluid annual change in the medium-term prediction index,etc. ② The Y value takes into account the weight coefficients of the prediction indexes at all levels,reducing the subjectivity of analyzing the earthquake situation from the abnormal frequency,and making the comprehensive prediction results more reasonable. The earthquake case test shows that there exists a clear linear relationship between the comprehensive judgment index Y and the earthquake magnitude,which gradually increases with the increase of the magnitude. ③ Since the Y value in northwest Yunnan better reflects the earthquake precursor intensity and abnormal reliability of moderately strong earthquakes,it provides us a quantitative decision-making basis for the comprehensive analysis of regional earthquake situation.