In the time history analysis,the selection of seismic waves has a significant impact on long-period and long-span bridges. Based on the standard target spectrum and MATLAB program,in this paper we select the optimal wavelet base and use the wavelet coefficient iteration method to achieve frequency domain adjustment,so that the seismic wave response spectrum can continuously approach the given target spectrum. Moreover,by using two parameters including relative error and long-period fitting parameter to make a comprehensive evaluation,we are able to select seismic waves applicable to long-period and long-span bridge in the time-history analysis,and to propose a whole-process batch wave selection method for long-period bridges. The method is applied to Fengjie Yangtze River Bridge,and the effects of wave selection are compared with Seismo Match wave selection software based on time domain adjustment method. The results of wave selections are applied to the time-history analysis of the background bridges. The results indicate that there exists the certain difference between the key section response obtained by the wave selection method in this thesis and the response obtained by the software wave selection in the transverse and vertical bridge directions. The method in this paper can provide references for wave selections in time-history analysis of long-period and long-span bridges.