This study uses the earthquake catalog from the Xinjiang Seismic Network and,based on Load/Unload Response Ratio(LURR)theory,calculates LURR values in the seismogenic areas before 20 earthquakes(19 groups)with M_S≥6.0 that occurred in Xinjiang from 2000 to 2025. The statistical relationship between anomaly scale and strong earthquake magnitude is examined,and the spatiotemporal evolution characteristics of LURR before strong earthquakes are further analyzed. The results indicate that significant LURR anomalies occur before M_S≥6.0 earthquakes in Xinjiang,showing a pattern of“gradual increase-peak-rapid decline-earthquake occurrence.” The anomalies last from several months to several years. The average interval from the anomaly peak to earthquake occurrence is 11 months,with 14.5 months for M_S≥7.0 earthquakes and 10 months for M_S≥6.0 earthquakes. Earthquakes generally occur during the weakening stage of anomalies,and the peak of LURR anomalies can serve as an indicator of an approaching strong earthquake. Spatial scanning results show that earthquakes generally occur within or near anomalous areas,while the duration,amplitude,and area of anomalies vary due to differences in seismogenic structure,calculation parameters,and earthquake magnitude. Effectively combining LURR time series,spatial anomaly distribution,and seismogenic structures can provide a reference for predicting moderate-to-strong earthquakes in Xinjiang.