The Load/Unload Response Ratio (LURR) method is effective in identifying pre-seismic anomalous variations in observational data. An examination of small-earthquake activity and geophysical observation data prior to the 2021 Yangbi M_S6.4 earthquake indicates that the LURR method can effectively extract pre-seismic anomalies. A distinct loading-unloading process was observed before the earthquake,and the timing of high LURR values was closer to the occurrence time of the event than the anomaly timing indicated by the raw observational curves. LURR calculations based on small-earthquake activity reveal a clear evolutionary pattern of enhancement,weakening,and eventual earthquake occurrence prior to the event. the area of significant anomalies underwent a progressive expansion-contraction process before the earthquake. Short-term anomaly signals during the two months preceding the event were the most pronounced,with a maximum LURR value of 3.1. Some geophysical LURR anomalies exhibit similar temporal and spatial evolutionary patterns,enabling more effective assessment of earthquake urgency and providing a new basis for short-term and imminent earthquake tracking in the Yunnan region.