Abstract The regulation of the National Significant Seismic Monitoring and Protection Regions is defined by the Law of the People' s Republic of China on Protecting Against and Mitigating Earthquake Disasters． The first stage of the implementation of the regulation in Chinese mainland was finished from 1996 to 2005． And the second stage is being carried on from 2006 to 2020． With the support of National Social Science Foundation，the paper follows up and evaluates the implementation from 1996 to 2012 in Chinese mainland． Based on analysis of earthquake examples and investigated data，we find that the effect of disaster mitigation is good，and propose the suggestions for improving the regulation of the National Significant Seismic Monitoring and Protection Regions．