A magnitude 7.4 earthquake hit Maduo,Qinghai Province,China at 02:04am(local time,CST)on May 22,2021. China Earthquake Networks Center reported the formal quick report in 9 minutes,and started to monitor the aftershocks immediately. Meanwhile,China Earthquake Networks Center organized some related institutions,and quickly produced 14 scientific data products of 9 categories. These products imply that this earthquake occurred in Bayan Har block,located between the Gande-Maduo faults and Gande south rim fault in terms of regional tectonics. The estimated intensity of the epicenter area reached IX degree with the focal mechanism of a strike-slip event. The aftershocks concentrate in a narrow NW-SE band with main shock located in its center. The rupture process is a bilateral mode and lasts 45s. The majority energy releases in the first 30s and the maximum slip reaches 4.5 meters in the shallow crust which may cause surface fracture.